Behavioral and pharmacological aspects of opioid dependence: mixed agonist-antagonists.
نویسندگان
چکیده
Suggestions to Contributors Tribute to Dr. Paul Lewis Munson 3 Agonist-induced Desensitization of the 3-Adrenergic Receptor-linked Adenylate Cyclase. T. KENDALL HARDEN 5 Behavioral and Pharmacological Aspects of Opioid Dependence: Mixed Agonist-Antagonists. WILLIAM L. WOOLVERTON AND CHARLES R. SCHUSTER 33 Pharmacology of Mesocortical Dopamine Neurons. MICHAEL J. BANNON AND ROBERT H. ROTH 53 Opioid Receptors: Autoradiography. JAMES K. WAMSLEY 69
منابع مشابه
Behavioral characterization of opioid mixed agonist-antagonists.
The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modif...
متن کاملPharmacological enhancement of naltrexone treatment for opioid dependence: a review
PURPOSE: Opioid dependence (OD) is a serious and growing clinical condition with increasing social costs that requires expanding treatment beyond opioid agonist substitution. The opioid antagonist naltrexone has displayed a remarkable association of theoretical effectiveness and poor clinical utility in treating OD due to noncompliant behavior and low acceptability among patients, only partly m...
متن کاملAcute opioid pretreatment potentiates naltrexone-induced drinking suppression in water-deprived rats.
Pretreatment with morphine-like agonists potentiates the behavioral effects of opioid antagonists, possibly reflecting a state of acute physical dependence. Several studies have used operant behavior to quantify these effects. However, little research has been done using unconditioned behavior. One objective of this study was to determine whether opioid agonist pretreatment (e.g., morphine, fen...
متن کاملConsequences of interaction between opioid and receptor.
Gaddum (1962) divided receptors into ‘pharmacological’ and others. Pharmacological receptors give a pharmacological response to binding of molecules of drug (including endogenous substances) and are blocked by specific antagonists. One such is the opiate receptor. Its ligands include opiates (derivatives or opium), opioid drugs (e.g. methadone, pethidine), opioid peptides (endorphins, including...
متن کاملOpioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series.
The development of the prototype synthetic delta-opioid receptor antagonist peptides TIPP [(H-Tyr-Tic-Phe- Phe-OH); Tic: tetrahydroisoquinoline-3-carboxylic acid] and TIPPpsi (H-Tyr-psiTic-Phe-Phe-OH) by Schiller and coworkers was followed by extensive structure-activity relationship studies, leading to the emergence of numerous analogs that are of pharmacological interest. Eight novel diastere...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Pharmacological reviews
دوره 35 1 شماره
صفحات -
تاریخ انتشار 1983